Organophosphorus Flame Retardants Inhibit Specific Liver

Organophosphorus Flame Retardants Inhibit Specific Liver Carboxylesterases and Cause Serum Hypertriglyceridemia

Humans are prevalently exposed to organophosphorus flame retardants (OPFRs) contained in consumer products and electronics, though their toxicological effects and mechanisms remain poorly understood. We show here that OPFRs inhibit specific liver carboxylesterases (Ces) and cause altered hepatic lipid metabolism. Ablation of the OPFR target Ces1g has been previously linked to dyslipidemia in mi...

Recent Developments in Organophosphorus Flame Retardants Containing P-C Bond and Their Applications

Organophosphorus compounds containing P-C bonds are increasingly developed as flame retardant additives due to their excellent thermal and hydrolytic stability and ease of synthesis. The latest development (since 2010) in organophosphorus flame retardants containing P-C bonds summarized in this review. In this review, we have broadly classified such phosphorus compounds based on the carbon unit...

Microbial Degradation of Persistent Organophosphorus Flame Retardants

Organophosphorus Flame Retardants (OPFR): Neurotoxicity

Organophosphorus flame retardants (OPFRs) are used as additives in plasticizers, foams, hydraulic fluids, anti-foam agents, and coatings for electronic components/devices to inhibit flames. These chemicals were developed and used as flame retardants because of environmental and health concerns of previously used brominated and chlorinated flame retardants (FRs). OPCFRs are divided into five mai...

Mineralization and Primary Biodegradation of Organophosphorus Flame Retardants in Activated Sludge

Halogen-free flame retardants (HFFRs), such as the aromatic organophosphorus flame retardants (OPFRs) triphenyl phosphate (TPP), resorcinol bis(diphenylphosphate) (RDP) and bisphenol A bis(diphenylphosphate) (BDP) have been proposed as potential replacements for brominated flame retardants in polymers and textiles. Although these OPFRs are already marketed, their environmental fate and effects ...